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- Usually do not take extra or twice doses.
- Interaction Eating, antacids, misoprostol acid is accompanied by a decrease in plasma concentrations clinically insignificant.
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Misoprostol has no clinically significant effect on prolactin levels of gonadotropins, thyrotropin, growth hormone, thyroxine, cortisol, creatinine, platelet aggregation, lung and heart function — vasculature. Once inside quickly and completely absorbed. The walls of the gastrointestinal tract and hepatic biotransformation to pharmacologically active metabolite of diester ; misoprostol acid.
Equilibrium concentration in plasma is achieved within 2 days, no accumulation is observed. In elderly patients over 64 years an increase in AUC. C max misoprostol acid in breast milk is reached in 1 hour and is 7. Application of the substance Misoprostol The erosion of the gastrointestinal tract.
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Contraindications Hypersensitivity, including to other prostaglandins and their analogs, breast-feeding, Children and Youth age up to 18. Restrictions on the use Severe hepatic dysfunction, renal failure, hypotension, ischemic heart disease. Application of pregnancy and breastfeeding When used as a gastroprotective agent.
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