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Ephedrine dilution technique (DESCRIPTION,DOSES, INDICATION AND DILUTION TECHNIQUE FOR SPINAL HYPOTENSION)

DESCRIPTION,DOSES,INDICATION AND DILUTION TECHNIQUE

DESCRIPTION

  1. Ephedrine is indirectly acting sympatomimetic drug
  2. It stimulates both alpha and beta adrenergic receptors which causes increase in heart and increase in blood pressure respectively.
  3. Alpha receptor acts on blood vessels where as beta receptors acts on heart.
  4. Ephedrine raises systolic and diastolic blood pressure by vasoconstriction and cardiac stimulation.
  5. Ephedrine is available in the USA as a non prescription medicine for relief of breathing problems .It is rarely used because there are safer and more effective medications (eg.albuterol, pseudoepherine )

PHARMACOLOGY

It causes

  1. CNS stimulation
  2. Cardiac stimulation
  3. Vasoconstriction
  4. Increase in blood pressure
  5. Bronchodilation
  6. Tachycardia
  7. Mydriasis
  8. Diuretics
  9. Stimulation of urine contraction
  10. Decrease in intestinal tone and motility

DOSE FOR THE HYPO TENSION DURING SPINAL ANESTHESIA 

Ephedrine is the indicated drug for the treatment of the spinal hypotension

Initial dose: 5-10mg IV bolus (Must be diluted)

Administer bolus dose according to the need but dose should not exceed 50mg .

 

DILUTION TECHNIQUE

Each 5mL ampule contains 50mg

Make 50mg per 10mL by adding 5mL distilled water.

After dilution each mL=50mg/10mL= 5mg

 

Ephedrine ampule=5mL(50mg)

Each mL(1mL)=50mg/5mL=10mg

Now lets make it 5mg/mL

Withdraw 5mL (50mg) Ephedrine in a 10cc syringe and add 5mL water for injection in it to make it 10mL

Now each mL contains : 50mg/10mL=5mg

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